![]() The sinusoidal and vascular ectasia progressively becomes more extensive, resulting in large, often confluent, cyst-like cavitations ( As the lesion progresses, affected areas enlarge and can compress adjacent parenchyma ( It is usually a spontaneous, age-related change, though treatment-related increased incidences have been reported after administration of certain chemicals.Įarly stages of cystic degeneration are characterized by small, noncompressive foci of widened cortical sinusoids and dilated blood vessels in the zona fasciculata cortical cells in the intervening cords can be vacuolated or slightly flattened. In all rat strains, cystic degeneration is much more common in females than in males. Incidences vary with rat strain, with some strains (e.g., Sprague-Dawley, Wistar) exhibiting much higher incidences than others (e.g., F344). ) occurs in many strains of rats but has apparently not been reported in mice. Cystic degeneration of the adrenal cortex ( ![]()
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